| Cubic centimeters (cm³) | Microliters (µL) |
|---|---|
| 1 Cubic centimeter | 1000 µL |
| 2 Cubic centimeters | 2000 µL |
| 3 Cubic centimeters | 3000 µL |
| 4 Cubic centimeters | 4000 µL |
| 5 Cubic centimeters | 5000 µL |
| 10 Cubic centimeters | 10000 µL |
| 20 Cubic centimeters | 20000 µL |
| 25 Cubic centimeters | 25000 µL |
| 50 Cubic centimeters | 50000 µL |
| 100 Cubic centimeters | 100000 µL |
| Reference | Cubic centimeters (cm³) | Microliters (µL) |
|---|---|---|
| A teaspoon | 5 cm³ | 5000 µL |
| A can of soft drink | 330 cm³ | 330000 µL |
| A wine bottle | 750 cm³ | 750000 µL |
| A bathtub | 150000 cm³ | 150000000 µL |
| An Olympic swimming pool | 2.5 × 109 cm³ | 2.5 × 1012 µL |
The cubic centimetre is a unit of volume equal to one millionth of a cubic metre, written cm³ and often abbreviated cc. It is the volume of a cube one centimetre on each side, and since the litre was redefined in 1964 it is exactly one millilitre. The two names describe the same quantity, but they belong to different trades and are not interchangeable in every context.
Engines are its most visible home. Motorcycle and small-engine displacement is quoted in cubic centimetres, so a 125, a 600 and a litre bike are named by the swept volume of their cylinders. Licence categories in much of the world are drawn on the same scale, with a 125 cc limit for learners in many European countries, which turns the unit into a legal boundary rather than a mere description.
Car engines cross over to litres at about a thousand cubic centimetres, purely for readability, so a 1998 cc engine is advertised as a two-litre. American practice used cubic inches for the same purpose well into the 1980s, and the conversion is worth knowing: 1000 cubic centimetres is 61 cubic inches, so a 350 cubic inch engine is 5.7 litres.
Medicine has deliberately retreated from the abbreviation. Syringes were once marked in cc and clinicians spoke that way, but handwritten cc can be misread as a unit symbol or as a pair of zeros, and medication safety bodies now place it on lists of abbreviations that should not be used. The instruction is to write mL instead, even though the quantity is identical.
Materials science keeps the unit for density. Grams per cubic centimetre is the standard way to state how heavy a substance is for its size: water is 1.00, aluminium 2.70, steel about 7.85, lead 11.34 and gold 19.3. Those numbers are memorable precisely because the cubic centimetre is small enough that everyday solids land between one and twenty.
Modelling and manufacturing use it for part volume. Computer-aided design reports the volume of a component in cubic centimetres, which converts directly to mass once a density is chosen and to material cost in additive manufacturing. It is the natural unit for anything that fits in a hand.
One cubic centimetre equals 1 millilitre, 1000 cubic millimetres, 0.000001 cubic metres, or about 0.061 cubic inches.
The microlitre is a unit of volume equal to one millionth of a litre, written µL. It is exactly one cubic millimetre. It is the working unit of the molecular biology laboratory and of clinical haematology, and almost every quantity in modern biological science that is not a mass or a concentration is a number of microlitres.
Pipetting is what defines it in practice. Adjustable micropipettes are named after their maximum volume in microlitres, so a bench holds instruments of 2, 20, 200 and 1000, and a researcher's day consists largely of moving microlitres from one tube to another. A polymerase chain reaction is typically assembled in twenty to fifty microlitres, and a whole experiment may use less liquid than a teaspoon holds.
Blood counts are reported against it. White cells number between four thousand and eleven thousand per microlitre in a healthy adult, platelets between a hundred and fifty thousand and four hundred thousand, and red cells about five million. Those reference ranges are among the most widely used numbers in medicine, and all of them are counts within a cube one millimetre on a side.
Diagnostics has driven the volumes down. A modern blood glucose meter needs about half a microlitre of blood, which is why a finger-prick sample is enough where an earlier generation of instruments needed a syringe. Point-of-care analysers, lateral flow tests and microfluidic cartridges are all designed around the smallest sample a patient can be asked to give.
Analytical chemistry uses the same scale. Injection volumes in liquid chromatography run from one to twenty microlitres, gas chromatography uses one or less, and mass spectrometry samples are prepared in tens. Because the analytical signal depends on the amount injected, the accuracy of a microlitre-scale measurement sets the accuracy of the whole result.
The identity with the cubic millimetre is a genuine convenience. Haematology once reported cell counts per cubic millimetre and now reports them per microlitre, and the numbers did not change at all, because the two units are the same. That is a rare case of a unit change in medicine that required no re-education and produced no errors.
One microlitre equals 1 cubic millimetre, 0.001 millilitres, 0.000001 litres, or about 0.0000338 US fluid ounces.