| Micrograms (μg) | Nanograms (ng) |
|---|---|
| 1 Microgram | 1000 ng |
| 2 Micrograms | 2000 ng |
| 3 Micrograms | 3000 ng |
| 4 Micrograms | 4000 ng |
| 5 Micrograms | 5000 ng |
| 10 Micrograms | 10000 ng |
| 20 Micrograms | 20000 ng |
| 25 Micrograms | 25000 ng |
| 50 Micrograms | 50000 ng |
| 100 Micrograms | 100000 ng |
| Reference | Micrograms (μg) | Nanograms (ng) |
|---|---|---|
| A sheet of A4 paper (80 gsm) | 5000000 μg | 5 × 109 ng |
| One litre of water | 1 × 109 μg | 1 × 1012 ng |
| Average adult human | 7 × 1010 μg | 7 × 1013 ng |
| A small car | 1.4 × 1012 μg | 1.4 × 1015 ng |
The microgram is a unit of mass equal to one millionth of a gram, or one thousandth of a milligram. Its official symbol is µg, written with the Greek letter mu.
In medicine that symbol is a known hazard. Handwritten, µg is easily read as mg, a thousandfold error, and the mistake has killed patients. Safety bodies including the Institute for Safe Medication Practices therefore recommend writing mcg instead on prescriptions and labels, and most hospital systems now enforce it. The abbreviation is not SI and would be wrong in a scientific paper, but it is the safer choice on a drug chart.
Micronutrients live at this scale. Vitamin B12, folate, iodine, selenium, biotin and vitamin K are all dosed in micrograms, and daily requirements run from a few micrograms to a few hundred. Vitamin D is given either in micrograms or in international units, with one microgram equal to forty IU, a dual convention that causes constant confusion on supplement labels. Potent drugs use the unit too: fentanyl, levothyroxine, digoxin and most hormonal contraceptives are dosed in micrograms rather than milligrams.
Air quality reporting has made the microgram familiar to the public. Fine particulate matter is measured in micrograms per cubic metre, and the World Health Organization guideline for annual PM2.5 exposure is five micrograms per cubic metre. Nitrogen dioxide, sulphur dioxide and ozone limits are written the same way, so the number quoted in a news report about pollution is almost always a count of micrograms in a cubic metre of air.
Toxicology works here because potency and hazard both scale with dose. Digoxin is prescribed in a few hundred micrograms a day and becomes dangerous not far above that, thyroid hormone is dispensed in 25-microgram steps, and the opioid fentanyl is active at doses of tens of micrograms, which is why illicitly mixed powders containing it are so often lethal. Analytical chemistry meets the unit from the other direction: modern instruments detect pesticides, metals and pharmaceuticals in water at concentrations of micrograms per litre, and regulatory limits are written at that level. A microgram is invisible, weighs less than a speck of dust, and yet is the natural unit for both the dose that heals and the dose that kills.
One microgram equals 0.001 milligrams, one millionth of a gram, and one thousand nanograms.
The nanogram is a unit of mass equal to one billionth of a gram, or a thousandth of a microgram. Its symbol is ng. Expressed in the base unit of the SI it is 10 raised to the power minus twelve kilograms.
Nothing historical stands behind the nanogram. It exists because SI prefixes extend without limit, and it became useful only when instruments grew sensitive enough to justify it. A good analytical balance resolves tenths of a microgram and stops there; no balance weighs a nanogram directly. The quantity is instead inferred, from the signal a mass spectrometer, an immunoassay or a chromatography column produces when a known volume of sample passes through it.
Clinical laboratories are where most people meet the unit without noticing. Hormone and drug concentrations in blood are reported in nanograms per millilitre: testosterone, prostate-specific antigen, digoxin, tacrolimus, and vitamin D in American practice. Therapeutic drug monitoring depends on the scale, because the difference between an effective and a toxic concentration of some drugs is a few nanograms per millilitre. Anti-doping thresholds are written the same way, which is why an athlete can test positive for a substance present in quantities invisible by any other measure.
Environmental chemistry uses it for the most toxic contaminants, where the interesting concentrations are far below anything a gram-scale unit describes comfortably. Dioxins and furans in air are reported in nanograms per cubic metre, mercury and polycyclic aromatic hydrocarbons in nanograms per litre of water. Regulatory limits for these substances are set at concentrations that only became measurable in the second half of the twentieth century, so the unit and the regulation arrived together.
The scale is hard to picture. A single grain of fine table salt weighs roughly sixty micrograms, which is sixty thousand nanograms. A typical mammalian cell weighs on the order of one nanogram, so a nanogram of tissue is a handful of cells. A microgram of anything is already invisible; a nanogram is a thousandth of that.
One nanogram equals 0.001 micrograms, one millionth of a milligram, and one billionth of a gram.