| Milligrams (mg) | Nanograms (ng) |
|---|---|
| 1 Milligram | 1000000 ng |
| 2 Milligrams | 2000000 ng |
| 3 Milligrams | 3000000 ng |
| 4 Milligrams | 4000000 ng |
| 5 Milligrams | 5000000 ng |
| 10 Milligrams | 10000000 ng |
| 20 Milligrams | 20000000 ng |
| 25 Milligrams | 25000000 ng |
| 50 Milligrams | 50000000 ng |
| 100 Milligrams | 100000000 ng |
| Reference | Milligrams (mg) | Nanograms (ng) |
|---|---|---|
| A sheet of A4 paper (80 gsm) | 5000 mg | 5 × 109 ng |
| One litre of water | 1000000 mg | 1 × 1012 ng |
| Average adult human | 70000000 mg | 7 × 1013 ng |
| A small car | 1.4 × 109 mg | 1.4 × 1015 ng |
The milligram is a unit of mass equal to one thousandth of a gram, or one millionth of a kilogram. Its symbol is mg. It is the smallest mass most people encounter by name, and the one printed on nearly every medicine box and nutrition label.
Pharmacy is built on it. Tablet strengths are quoted in milligrams almost universally, from a 500 mg paracetamol tablet to a 5 mg dose of a cardiac drug, and dosing by body weight is written in milligrams per kilogram. The unit suits the job because the therapeutic range of most oral drugs falls between one and a thousand milligrams, so doses can be stated as whole numbers without prefixes or decimals.
Nutrition labels use it for the minerals and for anything present in quantities too small for grams. Sodium, calcium, potassium, magnesium, iron and vitamin C are all listed in milligrams, and so is cholesterol. Caffeine content is given the same way: a strong cup of coffee holds roughly 100 mg, and regulators in several countries require energy drinks above 150 mg per litre to carry a warning.
In the laboratory the milligram is the comfortable working range of an analytical balance, which typically reads to a tenth of a milligram and settles within seconds. Below that, weighing becomes an exercise in controlling draughts, static electricity and the operator’s own body heat, which is why sub-milligram quantities are usually prepared by dissolving a larger weighed mass and taking an aliquot rather than by weighing directly.
Law and public health borrow it whenever a limit has to be enforceable. Drink-driving is defined in most of Europe as 50 milligrams of alcohol per 100 millilitres of blood, and in the United Kingdom as 80; food regulations cap sodium, additives and contaminants in milligrams per kilogram; and vehicle emission standards are written in milligrams per kilometre for particulates and oxides of nitrogen. In each case the number has to be small enough to matter biologically and large enough to be measured reliably in an ordinary testing laboratory, and the milligram sits at exactly that point. A cup of coffee carries about 100 milligrams of caffeine, which is a useful mental anchor for the whole scale.
One milligram equals 0.001 grams, one thousand micrograms, and one millionth of a kilogram.
The nanogram is a unit of mass equal to one billionth of a gram, or a thousandth of a microgram. Its symbol is ng. Expressed in the base unit of the SI it is 10 raised to the power minus twelve kilograms.
Nothing historical stands behind the nanogram. It exists because SI prefixes extend without limit, and it became useful only when instruments grew sensitive enough to justify it. A good analytical balance resolves tenths of a microgram and stops there; no balance weighs a nanogram directly. The quantity is instead inferred, from the signal a mass spectrometer, an immunoassay or a chromatography column produces when a known volume of sample passes through it.
Clinical laboratories are where most people meet the unit without noticing. Hormone and drug concentrations in blood are reported in nanograms per millilitre: testosterone, prostate-specific antigen, digoxin, tacrolimus, and vitamin D in American practice. Therapeutic drug monitoring depends on the scale, because the difference between an effective and a toxic concentration of some drugs is a few nanograms per millilitre. Anti-doping thresholds are written the same way, which is why an athlete can test positive for a substance present in quantities invisible by any other measure.
Environmental chemistry uses it for the most toxic contaminants, where the interesting concentrations are far below anything a gram-scale unit describes comfortably. Dioxins and furans in air are reported in nanograms per cubic metre, mercury and polycyclic aromatic hydrocarbons in nanograms per litre of water. Regulatory limits for these substances are set at concentrations that only became measurable in the second half of the twentieth century, so the unit and the regulation arrived together.
The scale is hard to picture. A single grain of fine table salt weighs roughly sixty micrograms, which is sixty thousand nanograms. A typical mammalian cell weighs on the order of one nanogram, so a nanogram of tissue is a handful of cells. A microgram of anything is already invisible; a nanogram is a thousandth of that.
One nanogram equals 0.001 micrograms, one millionth of a milligram, and one billionth of a gram.